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343 The additional unexpected observations from the GLP-1, GIP and GCGR tri-agonist studies 342,344 warrant further investigation, as these studies highlight the incomplete understanding of metabolic hormonal synergism, and that further elucidation of this will likely lead to more efficacious treatments for diseases such as T2D

Interested in this topic, you can read more in several articles: fat loss vs weight loss, the effects of medically induced weight loss on skeletal muscle, changes in fat-free mass during significant weight loss: a systematic review, and fat-free and skeletal muscle loss with GLP-1 treatments

doi:10.22038/ijorl.2020.43663.2442

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The decision depends on your health history, the severity of your initial weight struggle, and your personal preference regarding ongoing therapy

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