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To bridge this gap, the field needs to pursue advanced lipidomic profiling using patient biofluids (such as cerebrospinal fluid and plasma) to identify and quantify the specific oxidized PUFA species (e.g., oxPEs) that represent the ultimate executioners of the ferroptotic cascade [55,104]

doi:10.7150/ijbs.120980 This issue Cite Review 1

10.1016/0092-8674(93)90279-Y 20 Cappallo-ObermannH.SchulzeW.JastrowH.BauklohV.SpiessA

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Under physiological conditions, mitochondrial Ca 2+ uptake activates dehydrogenases in the TCA cycle, enhancing NADH generation and ATP production