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The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)
In clinical studies, Glutathione is well-tolerated at typical doses
Psychiatry 14:1142608
How does glutathione support antioxidants
ROS are primary effectors of cytotoxicity induced by treatment with anti-cancer drugs
The pros and cons of estrogens in prostate cancer: an update with a focus on phytoestrogens
