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The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]

Furthermore, the fibrillar type I and II collagens, become more denatured in degenerated IVDs (Antoniou et al., 1996)

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B12 helps combat this by supporting red blood cell production and oxygen transport

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After obtaining favorable results in the investigator-initiated Phase III trial JETALS, and following consultation withTokushima University, Eisai submitted a new drug application for the treatment of ALS in Japan in January 2024, leading to its approval in September, 2024 and leading to the launch today