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Cuproptosis increases the stability of NFE2L2 by suppressing its proteasomal degradation, leading to transcriptional upregulation of GCLC and GCLM and enhanced GSH synthesis, thereby suppressing cuproptosis in pancreatic cancer cells 169

It may be related to toxicity, oxidative damage, poor nutritional status or nutritional deficiencies, heavy metal or environmental toxicity, systemic disorders, hormonal imbalances, xenobiotic exposure, age-related decline, or obesity

8.6 Ferroptosis affects depression by regulating gut flora The brain-gut axis is a bidirectional communication network that connects cognitive and emotional functions of the brain to gut activity through neural pathways, neuroendocrine and neuroimmune systems, and gut microbiota (Mayer et al., 2022)

Conclusions and outlook Protein-based therapeutics have already revolutionized medicine and are increasingly growing in scope and impact

(B) The first-order reaction is an exponential curve in which concentrations fall fastest when they are highest

Despite the fact that G1 (a GPR30-specific agonist) promoted AMPK activation, the GPR30 antagonist G15 (1 M) was not available to attenuate the activity of Rd (Fig