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Plasma lipoproteins can be separated on the basis of their electrophoretic mobility, as shown in Figure 18.15, or on the basis of their density by ultracentrifugation

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The interaction between the hydrolases and the CW is crucial for their activity, and their subcellular localization regulated at the post-translational level reflects their targeting mechanisms (Vollmer et al., 2008b)

This results in the translocation of Parkin to the mitochondria and initiation of mitochondrial degradation [322, 323], which helps to maintain neuronal homeostasis [324]

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