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This leads to an increase in whole body radical burden, and increased oxidative damage to cell membranes

While the medulla is hyperosmolar to concentrate urine, its restricted blood supply results in a naturally hypoxic state

Ferroptosis, a novel Pharmacological mechanism of anti-cancer drugs
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doi: 10.1042/BST20140010

[DOI] [PubMed] [Google Scholar] 21.Mallet RT, Squires JE, Bhatia S, Sun J
