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This damage likely accelerates protein turnover, thereby impairing the energy-generating capacity of mitochondria

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It is thought that bioactive peptides derived from whey proteins as a result of gastrointestinal digestion or bioactive peptides in the whey protein mixture with antioxidant properties may also play a role in improving liver and kidney damage caused by MTX

Overall, IGF-1R expression is upregulated in breast tumors to a varying degree across subtypes, with higher expression observed in luminal A and B tumors than in HER2 + and TN tumors [63], an association that is likely related to the regulation of IGF-1R expression by ER

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If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs