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However, prolonged high doses of vitamin B12 can lead to various side effects: Anaphylactic shock: This allergic reaction to vitamin B12 is rare but very dangerous, potentially leading to death

PMCID: PMC5590688

There are better tests that are covered by insurance that can reveal thyroid disease up to a decade before a change in TSH is detected

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The W234R mutant was of interest due to its previously observed enhanced catalytic activity compared to the wild-type enzyme
