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Diabetic hearts have decreased myocardial GLUT4, glycolysis, and glucose oxidation, while there is a coincident increase in pyruvate dehydrogenase kinase, -oxidation, and myocardial oxygen consumption, all of which reflects an increase in fatty acid metabolism secondary to decreased glucose utilization

Together, these findings highlight the Goldilocks role of ROS: too little fails to induce effector T cell formation and instead promotes Tregs, whereas excessive or prolonged ROS drives exhaustion and apoptosis

In a review of seven long-term placebo-controlled studies in type 2 diabetics, acarbose reduced the risk of any cardiovascular event by 35% and the incidence of heart attack by 64% (Hanefeld 2004)

The association between glutathione and lead is more complex as GSH levels may be higher in those with lead toxicity (Gurer-Orhan 2004)

J Neurosci 29(40):1259712605 Rocchetti M et al (2013) Is cannabis neurotoxic for the healthy brain