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47 In the endothelial barrier injury associated with ARDS, several signaling pathways have been identified as key regulators, including METTL3-mediated N6-methyladenosine modification of tripartite motif-containing (Trim)59 mRNA, 80 NOX4 activation of CaMKII/ERK1/2/MLCK and Akt-FoxO1/3a signaling pathways, 81 as well as CREB-mediated transcription of VE-cadherin

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In many cases, ROS and oxidized lipids and proteins also function as signals that regulate gene expression to ensure appropriate acclimation or cell death responses

GSH depletion in vitro has also been shown to sensitize neurons to oxidative stress and mitochondrial dysfunction, leading to subsequent increases in ROS and apoptotic cell death
