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At 28 days after onset of hypoperfusion, rats treated with L-carnitine had increased phosphorylated Akt and mammalian target of rapamycin (mTOR), as well as increased levels of phosphorylated high-molecular weight neurofilament (pNFH) compared to vehicle treated rats [86]

The antinociceptive effect of ALC is mediated by increases in the expression of metabotropic glutamate receptor 2 (mGlu2) in the regions of CNS connected with pain transmission via an epigenetic mechanism involving the acetylation of the p65/NFkB complex [26]

Epub 2017 Jun 26

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