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Previous attempts at treatment and the severity of tissue damage also matter

Effects of lipoic acid on hepatic fat accumulation in rats fed methionine-and choline-deficient diet It has been shown that the diet of MCD can lead to the accumulation of intrahepatic fat, the mechanism is mainly due to the lack of choline in the diet caused by the body lecithin synthesis

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10.1146/annurev-biochem-052521-040754 Annu Rev Biochem

Duong T, Li X, Yang B, Schumann C, Albarqi HA, Taratula O, Taratula O (2017) Phototheranostic nanoplatform based on a single cyanine dye for image-guided combinatorial phototherapy