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Inhibition of xCT suppresses intracellular cysteine and stabilizes HIF1 [34]

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The electrophile reacts with proteins, DNA molecules, and phospholipids to exert toxic effects (dicarbonic stress) in the cells 5

8 It also initiates a powerful antioxidant torrent, increasing expression of superoxide dismutase (SOD), glutathione (GSH), catalase, and glutathione peroxidase (GPx)