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The 5xFAD mouse line has five mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, as well as the M146L and L286V mutations in PSEN1

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Reading the dose dial incorrectly happens more often than people admit

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Haan JB, Cooper ME (2011) Targeted antioxidant therapies in hyperglycemia-mediated endothelial dysfunction

This leads to a gradual loss of vision, which can develop from visual disturbances such as spots and fogginess, to an almost complete loss of sight
