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Biosci Biotechnol Biochem 61:19771980

Oral B12 (given sublingually) MB12 liquid The research used 500 mcg per day Although B12 is a very safe vitamin, always be on the lookout for these symptoms when using high doses: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet Possible explanations for elevated B12 (without supplementation) in the blood SIBO (Small Intestine Bacterial Overgrowth) SIBO may cause very elevated levels of B12 in the blood

doi: 10.1093/annonc/mdx479

Another study showed that pregnant womens exposure to extremely high doses of vitamin B12 could lead to the risk of autism spectrum disorder in an unborn child

doi: 10.1021/acsbiomaterials.9b00946

by mid-century with associated health care costs in excess of $500 billion [4,7]