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Conversely, the complete absence of ApoE expression in AD mouse models (APP/PS1 mice) containing both APP and PS1 mutations enhances A deposition and overall plaque size (Ulrich et al., 2018)

4 Translational challenges in TB vaccine development Despite advances in immunoinformatics and next-generation vaccine platforms, the translation of TB vaccine candidates into clinical success remains challenging (Ortega-Tirado et al., 2020)

The inclusion of these ingredients not only supports the gut barrier but also promotes a balanced inflammatory response, enhancing nutrient absorption, which can accelerate healing and boost systemic health

Basic Clin Pharmacol Toxicol 102:399407 Tan B, Piwnica-Worms D, Ratner L (2000) Multidrug resistance transporters and modulation

4.3 Clinical intervention studies: early therapeutic signals If the gut microbiota plays a meaningful role in FM, microbiota-targeted interventions should, at least in principle, improve patient outcomes (123)

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