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Precautions The usual precautions for parenteral administration should be observed

Single missed doses have minimal impact

And as you said, what is effective versus symptoms is most important at the end of the day

Federal regulations (45 CFR 46 Subpart B) provide additional protections for pregnant women and neonates, and IRB review cannot approve protocols that expose infants to unknown developmental risks without compelling scientific justification and robust preclinical safety data

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Changes often interpreted as angiogenesis may instead reflect alternative vascular phenomena such as remodeling, pericyte dropout, thickening of the basement membrane, or BBB disruption without true neovascularization (Sweeney et al