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The rationale is that smaller individual doses may reduce GI side effects while maintaining the same total weekly exposure

Diener, C., Keller, A

Influence of Niacinamide Containing Formulations on the Molecular and Biophysical Properties of the Stratum Corneum
192 Additionally, molecular biophysics research explores the role of integrins and other mechanosensitive proteins in mediating the cellular response to mechanical stress

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Indo Global J Pharm Sci 2 43.Saxen MA
