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The Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) trial was specifically designed to address the issue of efficacy and safety of fibrates in a prospective, randomized manner in 10,497 participants [59]

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In NAFLD patients, Godex supplementation significantly reduced ALT and AST, increased mtDNA copy number, and decreased oxidative stress marker 8-oxo-7, 8-dihydro2'-deoxyguanosine (8-oxo-dG) ( L-carnitine also ameliorates oxidative stress by reducing ROS production ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) ( Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis

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