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Since the blood-brain barrier prevents many dietary antioxidants from entering the brain, it largely relies on endogenous antioxidants such as Cu- and Zn-dependent superoxide dismutase (Cu, Zn SOD1)

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Nevertheless, it seems the obtained results have not provided sufficient preclinical evidence to consider resveratrol a good candidate for human trials

The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)
