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therefore, treatment should be started with small doses and gradually increased

These hydroxyl radicals can cause significant oxidative damage to cellular components, further disrupting mitochondrial redox homeostasis and contributing to mtROS accumulation (Paul et al., 2017

Additionally, gut microbiota alterations impact the efficiency of bile acid absorption in the ileum, reducing the activity of the apical sodium-dependent bile acid transporter (ASBT), leading to an increased flow of bile acids into the colon (54)

10.1038/cddis.2015.322 55 LiuY.TaoS.LiaoL.LiY.LiH.LiZ.et al (2020)

doi: 10.1200/JCO.2024.42.16_suppl.1051 263 BorgesVFChanALinNUTondaMEShilkrutMAlemanyCA