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Cell lysates from insect cells infected with wild-type or recombinant baculovirus 63-2-IV-2 were fractionated by CsCl density centrifugation

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Specifically, lactate mitigates inflammation by inhibiting TLR4-mediated signaling via GPR81, thereby facilitating the polarization of M2 macrophages and diminishing LPS-induced NF-B activation (154158) Additionally, lactate influences immune cell migration and cytokine production through its export via the monocarboxylate transporter MCT4

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Eur J Pharmacol 771:229235