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Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

We expressed and purified ABHD11-Flag in HEK293T cells and confirmed its hydrolase activity using a generic esterase substrate, p-nitrophenol acetate (Fig

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For cysteine reactivity profiling experiments, peptide ratios (signal intensity/sum of signal intensities per peptide) were calculated and cysteine aggregation was performed to aggregate signal intensities for multiple cysteines on the same peptide and multiple peptides for the same cysteine

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According to NICE guidance, Mounjaro is available for adults with type 2 diabetes meeting specific criteria, or for weight management in specialist services for those with BMI 35 kg/m (or 30 kg/m with weight-related comorbidities) and additional qualifying factors