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The good news is that clinical data tells us something encouraging
The enzyme activities were measured spectrophotometrically using commercially sourced ALT and AST activity assay kit (Sigma-Aldrich, India), according to the manufacturers protocol

However, its uncontrolled accumulation can lead to cell death

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Optimizing dosing of nitrofurantoin from a PK/PD point of view: What do we need to know

Cazzola M, Calzetta L, Page C, Jardim J, Chuchalin AG, Rogliani P, Gabriella Matera M
