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Placebo A substance or treatment that has no therapeutic effect used as a control treatment in randomized controlled trials

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Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology

Methods Synthesis of chemical compounds Details are collected in the Supplementary Information (Supplementary Figures 817 and Supplementary Methods) Stock solutions of Sav, 1 , 2 , ArM 2 x Sav, and ArM 2 x 5 y Sav x x y Sav-stock solutions (stock A ) were prepared in phosphate-buffered saline (PBS) (pH 7.5) or water to yield 800 M free biotin-binding site (referred to as FBBS)

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Autophagy maintains cellular homeostasis and energy production, to allow cells to function normally, and is a protective mechanism induced in response to multiple stressors [7, 8]