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The glioma tumour microenvironment (TME) has unique characteristics, such as hypoxia, the blood-brain barrier (BBB), reactive oxygen species (ROS) and tumour neovascularization

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This balance is critical for normal cellular processes and signaling

Biotransformation of the Naturally Occurring Isothiocyanate Sulforaphane in the Rat: Identification of Phase I Metabolites and Glutathione Conjugates

For instance, co-treatment with CBD and cisplatin promoted cell death in head and neck squamous cell carcinoma (HNSCC) in cellular assays and a xenograft animal model ( 19 and cisplatin showed strong synergistic effects with CIs in a range of 0.10.3 ( 19 and cisplatin did not significantly increase the iron and ROS levels in Caov-3 cells