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Kidney injury appears only as a secondary effect of dehydration from severe gut upset. Anti-drug antibodies form in roughly half to two-thirds of users but do not affect clearance, weight, or blood sugar. Benefits that look like side effects Tirzepatide lowers uric acid (about -0.7 to -1.0 mg/dL, mostly through weight loss) and lowers blood pressure

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D.SoldatovicI.ColakE.Sumarac-DumanovicM.JaneskiH.et al (2017)