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Minoxidils telogen effluvium during weeks 2-8 can cause temporary worsening before improvement
Induction of lipid ROS generation Intracellular ROS include superoxide anions, hydrogen peroxide, and hydroxyl radicals
Ferrous iron (Fe 2+ ) catalyzes the Fenton reaction with hydrogen peroxide, generating hydroxyl radicals ( OH) that extract hydrogen atoms from bis-allylic carbons of polyunsaturated fatty acids (PUFAs)
Binding of MTX and its polyglutamates can also be diminished by mutations in DHFR ( D )
Some patients remain at one dose long-term as a maintenance dose
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