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These may occur if: The injection was too shallow or too deep The fluid volume was too high for the site The product was too concentrated or acidic Local immune cells formed a small granuloma (harmless but annoying) Applying a warm compress can help disperse the fluid and reduce the lump

For example, senolytics may mitigate endothelial senescence, MMP inhibitors could prevent excessive extracellular matrix degradation, and anti-inflammatory interventions may help preserve microvascular integrity

PMID 28242228 52 Okajima K, Korotchkina LG, Prasad C, et al

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Chidlow et al., 2016)