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Likewise, kinetic analyses of 2-oxoglutarate transport in rat liver mitochondria indicated the presence of a single MichaelisMenten component with kinetic parameters in the range of those reported previously for kidney mitochondria (Coll et al., 2003)

doi: 10.1089/ars.2017.7172

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In the pathological environment of OA, various pathogenic stimuli have been confirmed to significantly impair System Xc function

MT-3 knockdown increases ROS levels, lowered by the antioxidant N-acetylcysteine

2.2.3 Metabolic interplay and plasticity between de novo synthesis and exogenous uptake Intracellular synthesis and extracellular uptake constitute two primary pathways for serine acquisition in cancer cells, operating independently yet synergistically to sustain tumor metabolism