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After obtaining spectral libraries for bright light images of unlabeled tissue and neuromelanin and fluorescent images of fluorophores and background autofluorescence, brightfield and fluorescent images were "unmixed" into individual signal components (i.e

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Mechanistically, we found that Usp2 deletion was associated with decreased protein levels of TFRC and TXNDC5, alongside enhanced ubiquitination of these targets in the kidneys post-UUO (Fig

The resultant effect of exposure to highly reactive intermediates is oxidative damage to proteins, lipids, and nucleic acids

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