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However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future

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[DOI] [PubMed] [Google Scholar] Wong 2006 Wong SSL, Wilczynski NL, Haynes RB

By inhibiting NNMT and preserving NAD, 5-Amino-1MQ triggers a metabolic shift toward greater energy expenditure