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the patient be closely monitored, and the rise in creatinine should remain within an acceptable range ( In a retrospective study of 213 metastatic renal cell carcinoma (mRCC) patients treated with first-line sunitinib at Gustave Roussy (20042013), hypertension was associated with longer overall and progression-free survival, while the use of angiotensin system inhibitor (ASI) independently conferred significant benefits in both outcomes

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Endothelial dysfunction is associated with decreased bioavailability of nitric oxide (NO) due to an increase in ROS, with a similar physiological change seen in cases of decreased GSH pools [16]

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[DOI] [PubMed] [Google Scholar] 5.Micali A., Pallio G., Irrera N., Marini H., Trichilo V., Puzzolo D., Pisani A., Malta C., Santoro G., Laur R., et al