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Eosinophil peroxidase (EPO) is highly basic, pI 10.8, localized in the matrix of the specific eosinophil granule and is a key participant in generating reactive oxidants and free radical species in activated eosinophils

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192 IDH mutations can also remodel the TME, affecting the frequency of tumor-infiltrating lymphocytes and modulating innate immune responses through ATRX and IDH1 mutation interactions

Acknowledgements We thank Textcheck for editing and reviewing the English in this manuscript