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Skipping of exon 14 removes Y1003, a key phosphorylation site required for CBL-mediated c-MET ubiquitination and subsequent degradation, resulting in aberrant c-MET accumulation and prolonged signaling, thereby driving unchecked cellular proliferation [45,46,47,48]

The major efficacy outcome measure was overall survival and additional efficacy outcome measures were time to disease progression, overall response rate, and response duration

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Vitamin B12 Injection should not be used if: Are allergic to cyanocobalamin or any of the inactive ingredients in Vitamin B12 Injection You have Lebers disease Tell your doctor about all of your medical conditions, past and present, before starting Vitamin B12 Injection

A 2025 narrative review of musculoskeletal research described both the regenerative findings and the open questions about translation to human clinical use (PMID 40789979)
