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These insoluble fibrils accumulate as Lewy bodies and Lewy neurites within the nerve cells

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Applied immediately after ketamine, it exhibited effects on NOS-1 (decreased expression), NOS-2 (increased expression), Plcg1 (decreased expression), Prkcg (increased, and then decreased expression), and Ptgs2 (increased expression), and it had no effect on NOS-3 and Ptk2 [171]

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Because regulatory approval requires: robust human clinical trials demonstrated efficacy established long-term safety These data are currently lacking