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Powerful Antioxidant Defense Glutathione and Vitamin C protect against free radical damage and environmental stress

A separate collapsing analysis of exome sequences from MacTel patients identified PHGDH haploinsufficiency as the most significantly enriched genetic change in this cohort, with numerous deleterious coding variants identified and confirmed via enzyme assay (26)

This review synthesizes current evidence on vitamin-mediated cellular pathways in LLD management, evaluates clinical efficacy across interventions, and proposes personalized nutritional strategies to optimize therapeutic outcomes

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