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For instance, muscle biopsies from ME/CFS patients have revealed cellular membrane damage, likely attributable to elevated levels of ROS (Pietrangelo et al., 2018)

Additionally, ALA sensitized NSCLC cells to apoptosis by downregulating the expression of PDK1, leading to a reduction in NRF2 levels and an enrichment of mitochondrial ROS [49]

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In addition, elevated GH in patients with poorly controlled type 1 diabetes mellitus was shown to induce podocyte injury and thereby may contribute to diabetic nephropathy

The chelation and sequestration of metals within fungal hyphae serve as a crucial mechanism for protection (Riaz et al