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In mouse models of obesity with high leptin concentrations, this protein may be protective against LV hypertrophy.117 Obese diabetic dB/dB mice (with functionally inactive leptin) show diastolic dysfunction with preserved LVEF, associated with cardiomyocyte hypertrophy, fibrosis and microvascular rarefaction ( Table 3 ).118 Leptin also acts on the kidney to promote sodium retention, thus increasing the secretion of aldosterone, the activity of the renal sympathetic nerves and the Na+-K+ ATPase in the renal tubules119 (opposite effect of sodiumglucose cotransporter 2 inhibitors) ( Table 3 )

Subcutaneous and visceral adipose tissue: structural and functional differences

five Firmicutes [Mitsuokella, Ruminococcaceae NK4A214 group ( Ruminococcus ) torques group, ( Bacteroides ) pectinophilus group, Eisenbergiella ]

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Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy

Mitochondrial respirometry