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However, GSH has an overall negative charge at physiological pH, and mitochondria also exhibit an enormous negative membrane potential [57, 58]

Cysteine is frequently identified as rate-limiting, which provides the rationale of why N-acetylcysteine (NAC) is frequently studied and suggested as a supplement for glutathione support [50], yet a review of the data indicates its use may be inconclusive or equivocal

Am J Clin Nutr 87: 1554S1557S, 2008 [DOI] [PubMed] [Google Scholar] 21.Gahche JJ, Bailey RL, Potischman N, and Dwyer JT