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T4 increases the production of pyroglutamyl peptidase II, an enzyme that degrades TRH in the hypothalamus [29]

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and types of included studies included, but were not limited to clinical trials, including randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs), which provided direct evidence on the effects of interventions

doi: 10.1038/nprot.2006.378

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Poly(-caprolactone) nanocomposite scaffolds for tissue engineering: a brief overview