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Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice

[] D = -5.45 (c = 0.11, DMSO), Rf = 0.44 (CH 2 Cl 2 /MeOH 8/2), 1 H NMR (400 MHz, DMSO) (ppm) 10.80 (s, 1 H, N H ), 7.90 (s, 1 H), 6.61 (s, 2 H), 5.68 (d, J = 6.0 Hz, 1 H, H-1), 5.57 (d, J = 6.1 Hz, 1 H, 2-O H ), 5.40 (d, J = 4.9 Hz, 1 H, 3-O H ), 4.64 (dd, J = 11.3, 5.8 Hz, 1 H, H-2), 4.104.05 (m, 1 H, H-3), 4.023.97 (m, 1 H, H-4), 3.71 (dd, J = 13.7, 5.5 Hz, 1 H, H-5a), 3.59 (dd, J = 13.7, 8.0 Hz, 1 H, H-5b), 2.83 (s, 3 H, thioAc C H 3 )

In another experimental setting, administration of 2% taurine (2/100 g diet) to rats fed a 50% calcium-deficient diet, has been shown to inhibit LPO in the liver, as compared to control rats (222)

9 Humans cannot synthesize vitamin C and must acquire it in the diet

The Keap1/NFE2L2 signaling pathway can modulate ferroptosis activation (72)

CNA0508965