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additive with GLP-1 Semaglutide Established CV outcomes Tirzepatide Highest single-agent obesity efficacy Retatrutide Triple-agonist mechanism Numbers reflect published Phase 3 endpoints where available

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Patients with type 2 diabetes or obesity may have additional risk factors for infections or other conditions that cause lymphadenopathy, making it essential to evaluate swollen lymph nodes thoroughly rather than automatically attributing them to GLP-1 therapy