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Furthermore, a critical driver of inflammation involves inflammasome activation in TBI (Liu et al., 2013), and studies in human subjects have shown that inflammasome components are detected in cerebrospinal fluid (CSF) are associated with worse clinical outcomes ( 6.5 Neurodegeneration involving diffuse axonal injury (DAI) Postmortem studies in human subjects have revealed diffuse axonal injury (DAI) as a common neuropathological feature of exacerbated TBI, including Wallerian-like degeneration following injury with white matter atrophy