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The figure below shows the mechanism of NAPQI generation and its further metabolism, as well as the possible mechanism of NAC in removing NAPQI

It delivers copper to lysyl oxidase, the enzyme responsible for cross-linking collagen types I and III into durable, organized fibers

Iron extravasation leading to skin staining is the adverse effect with the highest litigation risk

This could help answering whether glutamate in the GLAST KO model was indeed the rate-limiting substrate from GSH synthesis or if neurodegeneration was mainly due to glutamate neurotoxicity

MVASI (biosimilar
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