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Study shows that treatment with GSK864 as IDH1 inhibitor binding an allosteric site on IDH1 reduces the NADPH/NADP + ratio and prolongs the survival of glioblastoma multiforme (GBM) PDXs model

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in the Journal of Endocrinology and Metabolism reported AOD 9604 to be well-tolerated across tested doses, with no observed alterations in IGF-1 levels, blood glucose, or insulin sensitivity

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