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(3) Organ-centric reductionism: the current investigations predominantly focus on isolated organ systems, neglecting BBRs pleiotropic effects within inter-organ communication networks critical to systemic metabolic regulation

Patients with IGF receptor defects may have some degree of short stature

The same lever runs in reverse when growth disappoints, which is why PE underwriters stress-test capital structures against 30% EBITDA decline scenarios

However, the action of DSIP goes deeper it also affects the hypothalamus-pituitary axis, which can have a positive impact on the secretion of luteinizing hormone (LH)

Finally, targeted modulation of NFB and STAT3 pathways may offer selective protection against neuro-inflammation in dementia, for example using natural and rationally-designed inhibitors of the NFB pathway (as reviewed, Srinivasan and Lahiri, 2015) and small molecule STAT3 inhibitors which are effective in cancer models (Fletcher et al., 2011)