glutathione glutamine metabolism pathway metabolism: from proliferating cells to cardiomyocytes - Study proposes a new strategy

509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury

A.HoekstraP

By examining the effects of thyroid, parathyroid, pancreatic, adrenal, and sex hormones on hepatic metabolism and injury, the article provides a comprehensive overview of pathophysiological mechanisms and emerging therapeutic strategies

Three meta-analyses have been published on NAC administration in DILI

Learn how these shots can boost your energy, support weight management, and improve your well-being

2009;11(4):R120-R