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Our current understanding of AD pathologies involves various hypotheses, such as the cholinergic, amyloid, tau protein, inflammatory, oxidative stress, metal ion, glutamate excitotoxicity, microbiota-gut-brain axis, and abnormal autophagy

A proper history of polysaccharides referred to as immunomodulators can be traced to the 1940s, when Shear and Turner [10] described a polysaccharide substance isolated from the seaweed Serratia marcescens , that caused tumor necrosis

During this process, NH 3 is released and the lipoyl group of the H protein becomes reduced (dihydrolipoyl form)

Discussion PD has become a major burden on families and society, especially with the increases in the aging population worldwide

Pharm Res 22(4):636646 Xin X et al (2006) Extraction of 20 (S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation